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Glutathione: What It Is and Why It Matters

picture of a bowl with glutathione supplements, vitamin C, vitamin E, and liver detoxification supplements in it on a pink background
Should you take glutathione supplements?

What Is Glutathione?

Glutathione is often called the “master antioxidant” due to its powerful role in protecting the body from damage caused by oxidative stress and toxins. This small but mighty molecule is made up of three amino acids: glutamine, glycine, and cysteine. It’s naturally produced in every cell of your body, especially in the liver, which serves as your detox powerhouse.

What Does Glutathione Do?

Glutathione’s main functions include:

  1. Neutralizing free radicals: It helps minimize cellular damage caused by oxidative stress, reducing aging and disease risks.
  2. Supporting detoxification: Glutathione binds to harmful substances in the liver, making them easier to excrete. It is also involved in helping your body remove excess estrogen.
  3. Boosting the immune system: It enhances immune response by optimizing the function of white blood cells.
  4. Regenerating other antioxidants: It helps recharge vitamins C and E, ensuring your antioxidant defences remain strong.

How Does Your Body Make Glutathione?

Your body produces glutathione using the amino acids glutamine, glycine, and cysteine. While your cells are designed to produce it naturally, poor diet, chronic stress, pollution, aging, and illness can deplete its levels.

How to Boost Your Body’s Glutathione Levels

Eat Glutathione-Boosting Foods

    • Sulfur-rich foods like garlic, onions, and cruciferous vegetables (broccoli, kale, cauliflower) enhance cysteine availability.
    • Vitamin C-rich fruits and vegetables (citrus, bell peppers, strawberries) help regenerate glutathione.
    • Selenium-rich foods (Brazil nuts, eggs, seafood) act as cofactors for enzymes that rely on glutathione.

    Increase Protein Intake

    Ensure you’re eating enough high-quality protein sources to provide the building blocks for glutathione production.

    Focus on a Glutathione-Supportive Lifestyle

    Exercise regularly, sleep well, and reduce exposure to toxins like alcohol, tobacco, and processed foods to support natural production.

    Take Supplements That Support Glutathione

    N-acetylcysteine (NAC) and alpha-lipoic acid (ALA) are supplements that can enhance glutathione production. ALA also helps to recycle glutathione, manage blood sugar and prevent oxidative damage.

      Making the Most of Your Glutathione

      To optimize your existing glutathione levels:

      • Avoid overexposure to oxidative stressors like UV rays and environmental pollutants.
      • Manage stress through meditation, yoga, or other relaxation techniques.
      • Stay hydrated to support the detoxification process.

      Should You Take a Glutathione Supplement?

      Glutathione supplements are available in forms like oral pills, sublingual sprays, and intravenous infusions. However, there’s debate about their effectiveness:

      • Oral glutathione has limited bioavailability because it gets broken down in the digestive system.
      • Liposomal glutathione (encapsulated in fat) offers better absorption but costs more.
      • IV glutathione is highly effective for raising blood levels but is more invasive and expensive. (I do not do IV nutrients.)

      Is Supplementation Worth It?

      If you’re generally healthy, supporting your body’s natural production through diet and lifestyle is often sufficient. However, supplementation might be beneficial for those with chronic illnesses, high oxidative stress, or conditions like liver disease. Always consult a naturopathic doctor before starting a new supplement to make sure that you are taking it safely and effectively.

      The Bottom Line

      Glutathione is essential for maintaining optimal health, protecting against disease, and supporting youthful skin. While supplementation can be helpful in some cases, prioritizing a nutrient-rich diet, healthy habits, and glutathione enhancers like NAC and ALA are often the best ways to support your body’s natural production.

      Whether you’re looking to age gracefully, boost your detox systems, or simply feel more vibrant, nurturing your glutathione levels is a small change with big rewards.

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